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Mehrdad Abedi, M.D. Sandeep Krishna Agarwal, M.D., PhD. Stephen Clark, PhD. Patrizia Fuschiotti, PhD. Francesco Del Galdo, M.D., Ph.D. Daniel Tschumperlin, BSME, MSE, PhD. Heather Yowell, PhD.

1991 Grants
Investigator Institution Project Title Grant Duration Amt Granted
Stephen Clark, M.D. * VA Medical Center
Newington, Conn.
Genetic and molecular analysis of the tight skin locus in the mouse One Year $43,208
Benoit de Crombrugghe, M.D. ** University of Texas
Houston, Texas
Molecular mechanisms of Type I & III collagen synthesis in scleroderma fibroblasts One Year $43,972
William Earnshaw, Ph.D. * Johns Hopkins University
Baltimore, Md.
Development of improved assays for the detection of anti-centromere antibodies One Year $22,000
Robert Garver, Jr., M.D. * University of Alabama
Birmingham, Ala.
Growth factor expression protein production on the lower respiratory tract of individuals with scleroderma One Year $44,000
Barry Gruber, M.D. ** SUNY at Stony Brook
Albany, N.Y.
Role of mast cells in tryptase in the pathogenesis of scleroderma (renewal) One Year $40,973
Mary Jones, M.D. ** University of Iowa
Iowa City, Iowa
Investigation of immune dysregulation in a murine model of eosinophilia-myalgia syndrome One Year $44,000
G. J. Laurent, Ph.D. * National Heart & Lung Institute
London, England
Localization of transforming growth factor B in the lungs of patients with systemic sclerosis and assessment of its role in the regulation of collagen gene expression One Year $43,732
Gerd Maul, Ph.D. * Wistar Institute
Philadelphia, Penn.
Fibroblast and endothelial cells in pathogenesis of scleroderma One Year $44,000
James Norris, Ph.D. * Medical University of South Carolina
Charleston, S.C.
Analysis of the development of TSK phenotype and its linkage to chromosome One Year $43,560
Noelynn Oliver, Ph.D. ** Tufts University
Boston, Mass.
Fibronectin gene expression in abnormal wound healing One Year $44,000
Daniel Pennington, M.D.* North California Institute for Research and Education
San Francisco, Calif.
Purification of a mast cell-derived growth factor for fibroblasts One Year $43,845
Ignacio Sanz, M.D. * University of Texas
San Antonio, Tx.
Genetic basis of scleroderma specific autoantibodies One Year $44,000
Richard Silver, M.D. * Medical University of South Carolina
Charleston, S.C.
Cytokines and fibrosis in scleroderma lung disease One Year $44,000
Ethylin Wang Jabs, M.D. * Johns Hopkins University
Baltimore, Md.
Molecular mechanisms of antro-centromere antibody mediated chromosomal abnormalities in systemic sclerosis One Year $44,000
Barbara White Needleman, M.D. ** University of Maryland
Baltimore, Md.
Diversity of V (delta) 1/C (gamma) 2 bearing T cells in patients with scleroderma One Year $44,000
Frederick Wigley, M.D. * Johns Hopkins University
Baltimore, Md.
Assessment of peripheral circulation in patients with systemic sclerosis using continuous ambulatory skin temperature monitoring (CAST) One Year $34,166
Martin Zamora, M.D. * University of Colorado
Denver, Colo.
Cause and consequence of endothelial dysfunction in progressive systemic sclerosis: a potential contributor to vascular obstruction One Year $44,000
    Total Granted 1991:   $711,456

* Grant collaboratively funded by the Scleroderma Federation, the Scleroderma Research Fund, and the United Scleroderma Foundation.
** Grant funded solely by the Scleroderma Federation.

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